The Oligonucleotide Therapeutics Society’s Highly Anticipated Annual Meeting Returns in Person This Year

Featured Image for Oligonucleotide Therapeutics Society

Featured Image for Oligonucleotide Therapeutics Society

SAN DIEGO, Sept. 04, 2022 (GLOBE NEWSWIRE) — OTS is pleased to announce that, after two years of meeting virtually, the 18th Annual Oligo Meeting will include a robust in-person program live from Hilton Phoenix Resort at the Peak in Phoenix, Arizona, where delegates from many different countries can engage in lively discussions and enjoy interacting face-to-face once again. This year’s meeting, which will be held Oct. 2 – 5, is a hybrid event and will also include a virtual component allowing delegates who are unable to attend in person to enjoy the Annual Meeting from the comfort of their home or office.

The Oligonucleotide Therapeutics Society (OTS) is an open, nonprofit forum to foster academic and industry-based research and development of oligonucleotide therapeutics. The Founders’ vision was to bring together the expertise from different angles of oligonucleotide research to create synergies and to bring the field of oligonucleotides to its full therapeutic potential.

The OTS Annual Meeting is a forum for the realization of the Society’s mission and goals. At the annual meeting, anyone who is interested or involved in oligonucleotide therapeutics may attend and benefit from the incredible opportunity to learn from and engage with experts, post-docs, and students for a cross-disciplinary exchange, fostering the development of ground-breaking new ideas.

Due to the efforts and persistence of those in the field, multiple oligonucleotide therapeutic treatments have received approval from regulatory agencies around the world, two mRNA Covid-19 vaccines were created due to decades of prior development in the field, and over 100 oligonucleotide therapeutic treatments are in development for common conditions, including cancer and Alzheimer’s disease, as well as rare diseases. Incredibly, oligonucleotide therapeutics are being used to create individualized treatments for people with ultra-rare, fatal diseases.

Attendees of this year’s Oligo Meeting will hear from leading experts, students, and postdocs in the field from around the world. An array of intriguing topics will be covered, from chemistry, AI/machine learning, and genome and RNA editing to current preclinical and clinical research.

The Clinical Session is always engaging and inspiring, and this year’s session promises to continue the trend with topics such as Clinical Advances in CRISPR Cas9 Therapeutics, SLN360 and Controlling Lp(a), and Lessons Learned from ALS Clinical Trials. Speakers include notable authorities in the field at key roles in Biogen, Ionis Pharmaceuticals, Alnylam Pharmaceuticals, Intellia Therapeutics, Silence Therapeutics, and n-Lorem Foundation.

A special session is dedicated to celebrating the 20th anniversary of the Oligonucleotide Therapeutics Society, and attendees will have the privilege of hearing from founders of the OTS as well as past Board of Directors members who were there during the early days of the society, including Masad J. Damha, PhD, Gunther Hartmann, MD, PhD, Anastasia Khvorova, PhD, Art Krieg, MD, Mano Manoharan, PhD, Brett Monia, PhD, John Rossi, PhD, Georg Sczakiel, PhD, Hermona Soreq, PhD, and Cy Stein, MD, PhD.

OTS also has the privilege of presenting two OTS Lifetime Achievement Awards this year to individuals who have been influential in the field. Ryszard Kole, PhD, Professor Emeritus at the University of North Carolina, will be honored with the OTS Lifetime Achievement Award 2020 and C. Frank Bennett, PhD, the Senior Vice President of Research at Ionis Pharmaceuticals, will be honored with the OTS Lifetime Achievement Award 2021.

The Annual Meeting is open to anyone interested or involved in oligonucleotide therapeutics. Those wishing to attend in person or virtually can register at 2022oligomeeting.com.

Media Contact:

Geri Beaty
Phone: (619) 795-9458
Email: info@oligotherapeutics.org

Related Images

Image 1

s content was issued through the press release distribution service at Newswire.com.

Attachment

Solomon Islands Officials: Chinese Companies Still See Opportunity in Tulagi

Chinese companies are continuing to look for investment opportunities on Tulagi, one of the Solomon Islands a Chinese company tried, and failed, to lease in its entirety several years ago, authorities say.

Once the capital of the Solomon Islands before that role was moved to Honiara on the island of Guadalcanal, Tulagi is now home to Central Province’s capital.

The small island drew attention in 2019 when details became public about a long-term deal made by provincial leaders leasing the entire island to a Chinese company. National officials quashed the deal, which had raised fears that the company intended to develop infrastructure that could be used for military purposes.

Polycarp Galaigu, Central Province’s premier who took office in July, told VOA Mandarin last month that Chinese companies remain interested in investing in his province despite the flip-flop.

“We try to contact other businessmen to come and do their investment here in Central Province. But for now, I cannot tell you which company,” Galaigu said.

Galaigu said that some of the inquiries are from Chinese companies. Most are seeking opportunities in the fishing and tourism sectors, he said.

Allan Siale, Central’s provincial secretary, told VOA on Aug. 12 that several Chinese companies are interested in investing in coconut processing, fishing and tourism in the province’s Russell Islands, while others want to build factories on Tulagi. One company is interested in building an oil refinery, he said.

Sam Group, the company that tried to lease Tulagi outright, is still interested in investing, according to government records, he said.

Based in Beijing, Sam Group is a technology, investment and energy conglomerate founded in 1985 that has business relations with Solomon Islands, Brazil, Paraguay, Singapore and other countries, according to its website.

Sam Group did not respond to VOA’s request for comment.

Siale said Sam Group’s 2019 offer to lease Tulagi failed in part because it was not approved by the Solomon Islands Foreign Investment Division.

Stanley Manetiva, the former Central Province premier who made the initial lease deal with Sam Group, told VOA Mandarin on August 12 that he felt deceived by the Chinese company. He said it failed to follow the protocol that required signatures from a representative from the Chinese government, the Solomon Islands government and the company.

Company representatives “just drafted a document agreement, and they wanted you to sign it,” said Manetiva, who stepped down in July after a no-confidence vote.

Siale said that based on the proposal, the Sam Group didn’t intend to install military-related infrastructure on Tulagi. The company wanted to develop the island’s economic infrastructure: the roads, the airstrip and the seaport. “For military strategic infrastructure, as far as we recall, the agreement doesn’t mention anything to that effect,” Siale said.

Michelle Lam, a former employee of state-owned China Harbour Engineering Company (CHEC) in Solomon Islands, told VOA Mandarin that the suspicion that China’s Sam Group intended to lease Tulagi with military intent was nothing more than an exaggerated speculation.

“The Solomon Islands will be a port (for China) to supplement supplies and will never be a military base,” Lam said.

Citing an unnamed representative of CHEC, Lam said that the Chinese government has banned Chinese state-owned companies from participating in any bidding or development projects on Tulagi and nearby islands after the controversial lease was canceled.

Neither CHEC nor the embassy of China in Solomon Islands responded to a VOA request for comment.

Prime Minister Manasseh Sogavare, who has rejected concerns that a security deal with China will jeopardize regional safety, told The Guardian this July that there will never be a Chinese military base in his country.

Central Province officials signed the “strategic cooperation agreement” with China’s Sam Group on Sept. 22, 2019, one day after Sogavare officially cut ties with self-governing Taiwan and established diplomatic relations with China, which considers Taiwan its territory.

Solomon Islands officials terminated the Central Province deal with Sam Group on Oct. 25, 2019, saying provincial authorities lacked the right to enter a 75-year agreement for Tulagi island, which features the kind of deep-water harbor attractive to naval forces.

“It is settled practice that all agreements involving the Solomon Islands government, which includes the provincial governments, must be vetted by the attorney-general before it is executed,” said a statement issued by Sogavare’s office pointing out the Central Province deal with Sam Group omitted that step.

At the time, then-U.S. Secretary of Defense Mark Esper applauded the veto, calling it “an important decision to reinforce sovereignty, transparency and the rule of law.”

Source: Voice of America

Jehovah’s Witnesses Resume Door-to-Door work in US

Jehovah’s Witnesses have restarted their door-to-door ministry in the U.S. after more than 2½ years on hiatus due to the coronavirus pandemic, reviving a religious practice that the faith considers crucial and cherished.

From coast to coast, members of the Christian denomination fanned out in cities and towns Thursday to share literature and converse about God for the first time since March 2020.

In the Jamaica Plain neighborhood on the south side of Boston, Dan and Carrie Sideris spent a balmy morning walking around knocking on doors and ringing bells. Dan Sideris said he had been apprehensive about evangelizing in person in “a changed world,” but the experience erased any traces of doubt.

“It all came back quite naturally because we don’t have a canned speech,” he said. “We try to engage with people about what’s in their heart, and what we say comes from our hearts.”

The couple were surprised at how many people opened their doors and were receptive.

One man took a break from a Zoom call to accept their booklets and set up an appointment to continue the conversation. At another home, a woman spoke of how many family members died in the last two years — something the Siderises could relate to, both of them having lost parents recently. Another woman was too busy at the moment but spoke to Carrie Sideris through the window and said she could come back Sunday.

“I’ve been looking forward to this day,” she said. “When I rang the first doorbell this morning, a total calm came over me. I was back where I needed to be.”

Jehovah’s Witnesses suspended door-knocking in the early days of the pandemic’s onset in the United States, just as much of the rest of society went into lockdown, too. The organization also ended all public meetings at its 13,000 congregations nationwide and canceled 5,600 annual gatherings worldwide — an unprecedented move not taken even during the Spanish flu pandemic in 1918, which killed 50 million people worldwide.

Witnesses continued their ministry by writing letters and making phone calls, but it wasn’t the same because it lacked a personal touch, said Robert Hendriks, national spokesperson for the denomination.

“To us, going door to door is an expression of our God’s impartiality,” he said. “We go to everyone and let them choose whether they want to hear us or not.”

Anxiety, then and now

Even in pre-pandemic times, door-knocking ministry came with anxiety because Witnesses never knew how they would be received at any given home. In 2022 that’s even more the case, and evangelizers are being advised to be mindful that lives and attitudes have changed.

“It’s going to take an additional level of courage,” Hendriks said.

The organization is not mandating masks or social distancing, leaving those decisions to each individual.

The denomination has cautiously been rebooting other activities: In April it reopened congregations for in-person gatherings, and in June it resumed public ministry where members set up carts in locations such as subway stations and hand out literature.

But getting back to door-knocking, considered not just a core belief but also an effective ministry, is a big step toward “a return to normal,” Hendriks said.

Among those eager to pound the pavement again was Jonathan Gomas of Milwaukee, who started door-knocking with his parents when he was “big enough to ring a doorbell.”

“When you’re out in the community, you have your hand on the pulse,” he said. “We haven’t had that close feeling with the community for more than two years now. It feels like we’ve all become more distant and polarized.”

Gomas and his wife and two daughters have all learned Hmong in order to better reach out to members of that community, and residents are often pleasantly surprised to open their doors to fluent speakers of their language.

“I think it made them listen even closer,” he said.

‘Much more personal’

In Acworth, Georgia, Nathan Rivera said he has greatly missed seeing people’s faces and reading their expressions.

“You see and appreciate these responses, and it’s much more personal,” he said. “You establish common ground and relationships that you can never develop over the phone or by writing a letter.”

The son of Cuban refugees who came to the United States in the 1980s, Rivera said door-knocking is an important part of his spiritual identity and “feels Christ-like.”

“We show respect for each person’s right to hold a different belief,” he said. “If they don’t want to hear what we have to say, we politely thank them and move on, recognizing that we cannot judge anyone. We’ll just keep on knocking.”

Source: Voice of America

Tiafoe Ends Nadal’s 22-Match Slam Streak in US Open 4th Round

Frances Tiafoe ended Rafael Nadal’s 22-match winning streak at Grand Slam tournaments by beating the 22-time major champion 6-4, 4-6, 6-4, 6-3 in the U.S. Open’s fourth round Monday.

Tiafoe is a 24-year-old from Maryland who is seeded 22nd at Flushing Meadows and reached the second major quarterfinal of his career.

He is the youngest American man to get that far at the U.S. Open since Andy Roddick in 2006, but this was not a case of a one-sided crowd backing one of its own. Nadal is about as popular as can be in tennis and heard plenty of support in Arthur Ashe Stadium as the volume rose after the retractable roof was shut during the fourth set.

“I don’t even know what to say right now. I’m beyond happy. I can’t believe it,” said Tiafoe, who faces No. 9 seed Andrey Rublev next. “He’s one of the greatest of all time. I played unbelievable tennis today, but I don’t even know what happened.”

Here’s what happened: Tiafoe served better than No. 2 seed Nadal. More surprisingly, he returned better, too. And he kept his cool, remained in the moment and never let the stakes or the opponent get to him. The 36-year-old from Spain had won both of their previous matches, and every set they played, too.

“Well, the difference is easy: I played a bad match, and he played a good match,” Nadal said. “At the end that’s it.”

This surprise came a day after one of Tiafoe’s pals, Nick Kyrgios, eliminated the No. 1 seed and defending champion Daniil Medvedev. That makes this the first U.S. Open without either of the top two seeded men reaching the quarterfinals since 2000, when No. 1 Andre Agassi exited in the second round and No. 2 Gustavo Kuerten in the first.

That was before Nadal, Novak Djokovic, who has 21 Grand Slam titles, and Roger Federer, who has 20, began dominating men’s tennis. Djokovic, who is 35, did not enter this U.S. Open because is not vaccinated against COVID-19 and was not allowed to enter the United States; Federer, 41, has undergone a series of operations on his right knee and has not played since Wimbledon last year.

Now come the inevitable questions about whether their era of excellence is wrapping up.

“It signifies that the years go on,” Nadal said. “It’s the natural cycle of life.”

Either Tiafoe or Rublev will advance to a first major semifinal. Rublev, who is 0-5 in Slam quarterfinals, beat No. 7 Cam Norrie 6-4, 6-4, 6-4 earlier Monday.

The No. 1 woman, Iga Swiatek, covered her head with a white towel during one changeover after falling behind by a set and a break in her fourth-round match. She kept making mistakes, then rolling her eyes or glaring in the direction of her guest box.

Eventually, Swiatek got her strokes straightened out and moved into her first quarterfinal at Flushing Meadows by coming back to beat Jule Niemeier 2-6, 6-4, 6-0.

“I’m just proud,” Swiatek said, “that I didn’t lose hope.”

The 21-year-old from Poland will face another first-time U.S. Open quarterfinalist next. That’s No. 8 seed Jessica Pegula, the highest-ranked American woman, who advanced with a 6-3, 6-2 victory over two-time Wimbledon winner Petra Kvitova.

Nadal won the Australian Open in January and the French Open in June. Then he made it to the semifinals at Wimbledon in July before withdrawing from that tournament because of a torn abdominal muscle; that does not go into the books as a loss, because he pulled out before the match.

Nadal competed only once in the 1½ months between leaving the All England Club and arriving in New York while recovering from that injury. His play has not been up to his usual standards at the U.S. Open, which he has won four times.

The match ended when one last backhand by Nadal found the net. Tiafoe put his hands on his headm then he sat in his sideline chair with his face buried in a towel.

“When I first came on the scene, a lot of people had limitations on what I would do. … I wasn’t ‘ready for it mentally.’ I wasn’t ‘mature,’” Tiafoe said. But these days, he added, “I’m able to just do me and do it my way and enjoy the game I love.”

This represents the latest significant step forward for Tiafoe, whose only previous trip to a Grand Slam quarterfinal came at the 2019 Australian Open — and ended with a loss to Nadal.

Tiafoe thanked a long list of folks who were in the stands, including his parents — they emigrated from Sierra Leone in West Africa and his dad worked as a maintenance man at a tennis facility near the U.S. capital — his girlfriend and Washington Wizards All-Star guard Bradley Beal.

“To have them see what I did today means more than anything,” Tiafoe said. “Today’s an unbelievable day and I’m going to soak this one in, for sure.”

Source: Voice of America

Azerbaijani currency rates for September 5

BAKU, Azerbaijan, September 5. The official exchange rate of the US dollar and euro against Azerbaijani manat as of September 5, 2022 is set at 1.7 and 1.6833 manat, respectively, Trend reports via Central Bank of Azerbaijan (CBA).

According to CBA the manat rate to other currencies on September 5 is as follows:

Currencies Official exchange rate

1 US dollar USD 1.7

1 Euro EUR 1.6833

1 Australian dollar AUD 1.1539

1 Argentine peso ARS 0.0122

1 Belarus ruble BYN 0.6734

1 Brazil real BRL 0.3288

1 UAE dirham AED 0.4628

1 South African rand ZAR 0.0979

100 South Korean won KRW 0.124

1 Czech koruna CZK 0.0686

1 Chilean peso CLP 0.1938

1 Chinese yuan CNY 0.2452

1 Danish krone DKK 0.2264

1 Georgian lari GEL 0.5895

1 Hong Kong dollar HKD 0.2166

1 Indian rupee INR 0.0213

1 British pound GBP 1.9485

100 Indonesian rupiah IDR 0.0114

100 Iranian rials IRR 0.004

1 Swedish krona SEK 0.1567

1 Swiss franc CHF 1.7299

1 Israeli shekel ILS 0.4994

1 Canadian dollar CAD 1.2926

1 Kuwaiti dinar KWD 5.5093

1 Kazakh tenge KZT 0.0036

1 Kyrgyz som KGS 0.0209

100 Lebanese pound LBP 0.1124

1 Malaysian ringgit MYR 0.3788

1 Mexican peso MXN 0.0851

1 Moldovan leu MDL 0.088

1 Egyptian pound EGP 0.0884

1 Norwegian krone NOK 0.169

100 Uzbek soum UZS 0.0155

1 Polish zloty PLN 0.3555

1 Russian ruble RUB 0.0282

1 Singapore dollar SGD 1.2098

1 Saudi riyal SAR 0.4523

1 SDR (Special Drawing Rights of IMF) XDR 2.2103

1 Turkish lira TRY 0.0933

1 Taiwan dollar TWD 0.0553

1 Tajik somoni TJS 0.1668

1 New Turkmen manat TMT 0.4857

1 Ukrainian hryvna UAH 0.0461

100 Japanese yen JPY 1.2112

1 New Zealand dollar NZD 1.0354

Source: TREND News Agency