Announcing Winners of the €50,000 XR Research Awards and Open Call for New Applicants

The first XR Research Awards received great interest with 319 applications and 89 proposals. The XRRA provided a new opportunity for researchers and content creators to apply to a €50,000 fund to study behaviour in VR and promote the use of objective data to understand human behavioural responses in VR.

XR Research Awards

XR Research Awards

UNITED NATIONS, Jan. 13, 2022 (GLOBE NEWSWIRE) — The XR Research Awards targeted worldwide researchers, content creators or individuals affiliated with academic, research, clinical, rehabilitation, or commercial organizations. The proposals had to integrate biosensors to provide for objective outcome measures to be eligible. The awards from Emteq Labs, Cognitive3D, Pico and Plux Wireless Biosignals provide cash, equipment and support for projects.

Of the 319 applications and 89 proposals, 12 solutions stood out. The finalists were judged by leaders in the fields of scientific research, biosignals, safety and business. The proposals were judged on the following criteria: focus on validating the effectiveness of VR, team collaboration, working with partners in two or more organizations and having clear defined outputs.

The winners are:

1st prize: “The impact of social reciprocity on attitudes and behaviour in virtual social interactions” by Dr. Leon Kroczek, Dipl.-Psych.

Face-to-face interactions are a fundamental part of our life and Virtual Reality is a promising tool to study social behaviour. The XRRA award allows us to take VR research on social interactions to the next level by implementing an ecologically valid, real-time interaction paradigm based on eye gaze and facial expressions. This project will advance our understanding of social behaviour during real-time social interactions,” commented Dr. Leon Kroczek, winner of first prize

In addition to the two runner-up awards, an additional runner-up prize was given this year due to the number of quality submissions.

1st runner-up prize: “Development of a framework for emotional audio research (EAR) that uses biofeedback to deepen the immersive experience through the real-time integration of data from various biosensor inputs, which adaptively modify and enhance auditory content” by Richard Warp, Producer at Pollen VR, London

2nd runner-up prize: “Investigating the Effectiveness of Treating Pain and Anxiety with Virtual Reality Using Physiological Data” by Omer Liran, Co-director of Virtual Medicine at Cedars-Sinai, Los Angeles

3rd additional runner-up prize award went to the proposal for “Augmented Interoception: Parameters of Pain” by Hamid Ghaednia, Research Scientist at Massachusetts General Hospital, Boston

The judges were very impressed by the number and caliber of submissions to this first XR Research Awards. There’s tremendous excitement in the metaverse, but clearly, more research is needed to ensure that XR is rolled out safely and with a strong evidence base. We are delighted to announce that the XR Research Awards will continue in 2022, and we invite entrants to register for the new competition at www.xrra.net,” commented Dr. Charles Nduka, CEO and Scientist of Emteq Labs.

Discover more about the XR Research Awards from the article published at Emteq Labs or contact us at info@emteqlabs.com

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Final Entry Deadline Extended in the 2022 Stevie® Awards for Sales & Customer Service

Entrants Can Submit Nominations in the Top Sales and Customer Service Awards Through February 2

Stevie Awards for Sales & -Service

The 2022 Stevie Awards for Sales & Customer Service has extended the final entry deadline through February 2.

FAIRFAX, Va., Jan. 13, 2022 (GLOBE NEWSWIRE) — By popular demand, the Stevie® Awards have extended the final entry deadline in the 16th annual Stevie® Awards for Sales & Customer Service to Wednesday, February 2. The original entry deadline was January 12. These are the world’s premier awards for sales and customer service professionals, teams, and organizations.

Entry kits and complete details on the competition are available at http://www.StevieAwards.com/Sales.

Eligible nominees include departments, teams, and professionals from around the world who work in customer service, contact center, business development, and sales. New products and services and solution providers used by those professionals are also eligible. The 2022 awards will recognize achievements since July 1, 2019.

Winners will be announced on February 28, 2022. Gold, Silver, and Bronze Stevie Award winners will be celebrated at a virtual awards ceremony on May 11.

The Stevie Awards for Sales & Customer Service feature more than 150 sales awards, customer service awards, business development awards, new product awards, and solution provider awards categories. Entrants may submit any number of nominations to any number of categories.

New this year, for all categories the submission requirements have been extended to allow nominations to include accomplishments for the past two years instead of one.

There are many new categories for 2022 including Sales Engineer of the Year, Sales Support Professional of the Year, Virtual and Pre-Sales Professional of the Year, Remote Sales Innovation of the Year, Sales Employer of the Year, and an entirely new section of categories to recognize Thought Leadership achievements in business development, customer service, and sales.  Explore all of the categories here.

The Stevie Awards is also pleased to present the Ethics in Sales Award, sponsored by Sales Partnerships. This category has no entry fee. This award recognizes organizations for best practices and achievements in demonstrating the highest ethical standards in the sales industry. Entrants can submit specific examples, case studies, practices, etc. that illustrates why the organization being nominated should be considered an excellent example of best practices in sales. This award is based on activities in 2021.

Stevie Awards President Maggie Miller states, “Every year our judges grow more and more impressed with the submissions in the Stevie Awards for Sales & Customer Service. We encourage any organization who wants to be recognized for their achievements since July 2019 to request an entry kit to see which categories would best highlight those successes.”

Winners of the 2021 edition of the Stevie Awards for Sales & Customer Service included American Red Cross, Blackbaud, Inc., Carbonite, Cisco Systems Inc., ClassicCars.com, DHL Express, ElectronicArts, GoDaddy, IBM, John Hancock Financial Solutions, Land O’Lakes, Mailchimp, Modern Campus, Nasdaq Governance Solutions, Nutrisystem, Paylocity, SoftPro, Travelzoo, ValueSelling Associates, VIZIO, Inc., Vodafone Turkey, and more.

The 2022 competition will be judged by more than 150 professionals around the world.

About the Stevie Awards
Stevie Awards are conferred in eight programs: the Asia-Pacific Stevie Awards, the German Stevie Awards, The American Business Awards®, The International Business Awards®, the Stevie Awards for Great Employers, the Stevie Awards for Women in Business, the Stevie Awards for Sales & Customer Service, and the Middle East & North Africa Stevie Awards. Stevie Awards competitions receive more than 12,000 entries each year from organizations in more than 70 nations. Honoring organizations of all types and sizes and the people behind them, the Stevies recognize outstanding performances in the workplace worldwide. Learn more about the Stevie Awards at http://www.StevieAwards.com.

Marketing Contact:
Nina Moore
Nina@StevieAwards.com
+1 (703) 547-8389

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Madison Realty Capital Originates $345 Million Loan for St. Regis Residences on Boston Waterfront

NEW YORK, Jan. 13, 2022 (GLOBE NEWSWIRE) — Madison Realty Capital, a vertically integrated real estate private equity firm focused on debt and equity investment strategies, today announced that it has originated a $345 million loan to Cronin Development for the completion of a 22-story, 114-unit residential and retail condominium development at 150 Seaport Boulevard in Boston, Massachusetts.

The property will contain a mix of one-bedroom to six-bedroom penthouse residences with waterfront views, a majority of which will feature outdoor space, and 10,211 square feet of retail. The Residences will feature a full range of amenities, including a fitness and wellness center with a spa and jacuzzi, bistro-style restaurant with waterfront dining, a grand lounge and pool overlooking the harbor, boardroom, business center, catering kitchen, wine vault, and two guest suites, all managed by St. Regis residential staff.

Josh Zegen, Managing Principal and Co-Founder of Madison Realty Capital, said “Boston’s Seaport District is expanding rapidly, but high barriers to entry and long entitlement processes have constrained the supply of luxury condominium offerings. We are pleased to expand our presence in Boston to deliver an attractive and complex financing solution mid-construction for a significantly presold property to Cronin Development, a developer with over twenty years of experience developing and managing real estate projects in the Boston area. This transaction reflects Madison Realty Capital’s ability to deliver unique financing and certainty of execution for residential projects in every phase of development.”

Jon Cronin, Founder of Cronin Development, said “We are thrilled to engage Madison Realty Capital as a single source of financing to complete this luxury residential product, which will be the last waterfront residential development in the Seaport District. Madison Realty Capital was able to leverage its knowledge of the Boston condominium market to quickly and efficiently provide us a tailored financing solution during the construction process that will enable us to complete the project in the near term.”

Madison Realty Capital has significant experience investing in Boston. Notable transactions include a $165 million loan to Scape North America for the development of a 451-unit multifamily project in Boston’s Fenway neighborhood and a $314 million construction loan to Raffles Boston Back Bay Hotel & Residences.

About Madison Realty Capital 

Madison Realty Capital is a vertically integrated real estate private equity firm that, as of December 31, 2021, manages approximately $8 billion in total assets on behalf of a global institutional investor base. Since 2004, Madison Realty Capital has completed approximately $20 billion in transactions providing borrowers with flexible and highly customized financing solutions, strong underwriting capabilities, and certainty of execution. Headquartered in New York City, with an office in Los Angeles, the firm has approximately 70 employees across all real estate investment, development, and property management disciplines. Madison Realty Capital has been frequently named to the Commercial Observer’s prestigious “Power 100” list of New York City real estate players and is consistently cited as a top construction lender, among other industry recognitions. To learn more, follow us on LinkedIn and visit www.madisonrealtycapital.com.

Nathaniel Garnick/Grace Cartwright
Gasthalter & Co.
+1 (212) 257 4170
madisonrealty@gasthalter.com

STACK Infrastructure expands APAC footprint with new 36MW campus in Inzai, Japan

Milestone follows recent announcement of STACK’s entrance to APAC market with the opening of its Singapore regional headquarters

STACK Japan Data Center Rendering

DENVER, SINGAPORE and TOKYO, Jan. 13, 2022 (GLOBE NEWSWIRE) — STACK Infrastructure (“STACK” or the “Company”), the digital infrastructure partner to the world’s most innovative companies, today announced a partnership with funds managed by Oaktree Capital Management, L.P. (“Oaktree”), a leader among global investment managers specializing in alternative investments, to develop a 36MW data center campus in Inzai, Japan. The project will break ground in 2Q 2022 with capacity expected to be delivered in 4Q 2023.

STACK’s new Inzai campus will include two buildings totaling 36MW of critical capacity and is ideally located in an area of Tokyo that has seen significant hyperscale data center growth. Each building will have 18MW and separate access points to accommodate multiple users with separation of security and services. The new development will provide scalability and redundancy by connecting to regional substations powered by Tokyo Electric Power Company. The campus, with options for potential campus expansion beyond the initial 36MW, will offer hyperscale and enterprise clients a facility that is designed to enable higher rack density and floor loading specifications, reflecting the evolving requirements in Inzai and the APAC region more broadly.

This partnership pairs STACK’s global excellence in data center development and operations with Oaktree’s leading real estate platform and local resources which enables accelerated entry into the Japanese data center market. STACK brings expertise, talent, and capital to its partners to help them develop their strategic land parcels. STACK has assembled a world class in-country team, to lead the development and operations efforts in Japan.

“STACK’s expansion into Japan exemplifies our focus on establishing a scalable presence in markets that are strategically important to our clients,” said Pithambar (Preet) Gona, STACK’s Chief Executive Officer – APAC. “The decision to enter Japan, a critical location for hyperscale customers, demonstrates STACK’s ability to leverage our partnership model, capital, expertise and ability to attract leading talent in the industry to the STACK platform.”

“We are excited to partner with STACK to accelerate their international expansion in this critical region,” said Hideya Takahashi, Senior Vice President of Oaktree. “STACK’s industry-leading innovative technical solutions paired with Oaktree’s experience in providing ideal locations and infrastructure in the region, will result in a 36MW campus that is looking to exceed the highest level of expectations from clients.”

On the heels of a tremendous year of growth in 2021, STACK kicks off 2022 by adding another international campus to its growing global footprint. Recently STACK also announced the upcoming commissioning of a 24MW facility in Portland, and reported plans to enter Singapore, South Korea, Australia, and other Asia Pacific markets after Japan. STACK also offers several other opportunities in key regions throughout the United States and Canada, including:

  • A 19-acre data center campus in Toronto, Canada with 8MW coming available in Q3 2022 and an additional 48MW planned to be introduced in future phases starting in 2023
  • A 125-acre Northern Virginia campus now in its second phase of expansion, which will grow critical capacity to 72MW and come online starting in Q4 of 2022
  • A 30-acre data center campus in Portland, Oregon with immediate shell and commissioned capacity and future phases totaling 84MW
  • A 400-acre hyperscale data center campus with 400MW potential critical capacity in AllianceTexas, a master-planned development in Fort Worth, Texas, in partnership with Hillwood
  • A New Albany, Ohio 42MW data center campus with immediately available and build-to-suit expansion opportunities
  • A new 79-acre hyperscale data center campus in Avondale, Arizona, with 150MW of potential critical capacity
  • Build-to-suit opportunities in Atlanta, Georgia, including a potential 12MW in Alpharetta and a 48MW campus in nearby Lithia Springs

ABOUT STACK INFRASTRUCTURE
STACK provides digital infrastructure to scale the world’s most innovative companies. With a client-first approach, the Company delivers an extensive geographic footprint spanning the United States, Canada, and Asia Pacific with a comprehensive suite of wholesale build-to-suit, colocation, and powered shell solutions. With unparalleled existing and flexible expansion capacity in the leading availability zones, STACK offers the scale and geographic reach that rapidly growing hyperscale and enterprise companies
need. The world runs on data. And data runs on STACK.

For more information about STACK, please visit: www.stackinfra.com.

ABOUT OAKTREE

Oaktree is a leader among global investment managers specializing in alternative investments, with $158 billion in assets under management as of September 30, 2021. The firm emphasizes an opportunistic, value-oriented and risk-controlled approach to investments in credit, private equity, real assets and listed equities. The firm has over 1,000 employees and offices in 19 cities worldwide. For additional information, please visit Oaktree’s website at http://www.oaktreecapital.com/.

Media Contacts
Sammer Khalaf
press@stackinfra.com

Oaktree
mediainquiries@oaktreecapital.com

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HAS Healthcare Advanced Synthesis launches as an independent business

HAS Healthcare Advanced Synthesis launches as an independent business

Biasca, SwitzerlandJanuary 13, 2022 – HAS Healthcare Advanced Synthesis SA (the “Company”), a full-service contract development and manufacturing organization (CDMO) delivering high-quality, exclusive, personalized solutions to its healthcare clients, today announces its launch as an independent business. Originally established as part of the Helsinn Group by the Braglia family, under the name Helsinn Advanced Synthesis SA, the Company has been a CDMO since 1984.

The transition into a privately owned, independent company reflects the growth of the Company over the past years and a desire to fully focus the Company on delivering the best CDMO standards to its healthcare clients. As a subsidiary of the newly formed 3B Future Holding SA (also wholly owned by the Braglia Family) and supported by a team of passionate senior executives with extensive experience and skills in contract manufacturing for the pharmaceutical industry, HAS Healthcare Advanced Synthesis believes it is well placed to serve its clients as an innovative and technology-advanced manufacturing plant. The Company’s executive team will remain in place and Waldo Mossi, previously General Manager, has been appointed as Chief Executive Officer. Mossi, who has been with the Company for 27 years, has led the Company as General Manager for the past 8 years.

HAS Healthcare Advanced Synthesis’ dedicated team will continue to offer exclusive, personalized services to its clients, including the development and manufacturing of Active Pharmaceutical Ingredients (APIs), cGMP Advanced Intermediates, High Potency APIs (HPAPIs) and anticancer compounds, and to support its clients with their analytical and regulatory requirements. Over the years, the Company has always strived to deliver a cutting-edge service to its clients on their major projects and has done so by investing in innovative technology within its plants while striving to reduce the impact of its activities on the environment. Going forward,

HAS Healthcare Advanced Synthesis intends to build new laboratories to further strengthen its pharmaceutical offering and to anticipate future regulatory requests.

To view the new HAS Healthcare Advanced Synthesis website, please follow this link.

Waldo Mossi, CEO of HAS Healthcare Advanced Synthesis, commented: “We are thrilled to announce this exciting next step for HAS Healthcare Advanced Synthesis. Having spent the last decade developing our facilities, with investment totalling over CHF 100 million, we are excited by the prospect of supporting our clients and all of their manufacturing needs as an independent business. Our passion to deliver the best outcomes will remain unchanged, underpinned by the experience and know-how synonymous with our team. I feel honored to serve as CEO and to have been given this golden opportunity to lead HAS Healthcare Advanced Synthesis through this important milestone for the Company.

Riccardo BragliaChairman of the HAS Healthcare Advanced

Synthesis Board, commented: “The Braglia family is proud to see HAS Healthcare Advanced Synthesis officially launch as a business independent from Helsinn. It is a testament to the team’s sustained commitment to delivering tailored solutions to its clients and its focus on quality, reliability, supply chain management and safety. I would like to personally thank Waldo Mossi for his 27 years of service and am delighted that he has accepted the new role of CEO. Waldo, alongside the HAS Healthcare Advanced Synthesis Board, will form the leadership team to guide the company on its next strategic steps as a leading full-service CDMO delivering high-quality exclusive, personalized solutions to its healthcare clients.”

About HAS Healthcare Advanced Synthesis

HAS Healthcare Advanced Synthesis is a full-service CDMO committed to providing a reliable, first-class and tailor-made offering. The company develops and manufactures Active Pharmaceutical Ingredients (APIs), cGMP Advanced Intermediates, High Potency APIs (HPAPIs) and anticancer compounds for its clients from clinical to commercial supply, on an exclusive basis.

The production plant is located in Biasca, Switzerland and was established in 1984. The site is routinely inspected by the FDA, SwissMedic, and other global regulatory agencies. Production scale ranges from grams to tens of kilograms for HPAPIs and Anticancer compounds from kilograms up to tens of tons (APIs) in plants fully dedicated to cGMP manufacturing.

Please visit our new website: https://www.hashealthcare.com

For more information:
HAS Healthcare Advanced Synthesis Media Contact

Biasca, Switzerland

Giulia Rigonalli

Tel: +41 (0) 91 873 94 00

Email:   mediarelations@hashealthcare.com

For more information, please visit https://www.hashealthcare.com

Remington and Manchester United Extend Partnership

Manchester United Head of Academy Highlights Importance of Individuality and Confidence for Young Players

Remington Extends Partnership with Manchester United

Remington Extends Partnership with Manchester United

MANCHESTER, England, Jan. 13, 2022 (GLOBE NEWSWIRE) — Spectrum Brands Holdings, Inc. (NYSE: SPB) and Manchester United (NYSE: MANU) jointly announced today the extension of their global partnership, which will see Spectrum Brands’ iconic Remington personal care brand continuing its successful partnership as Manchester United Official Electrical Styling Partner.

As part of the announcement, Manchester United Head of Academy, Nick Cox, has spoken about the importance of instilling confidence in young players coming through the ranks.

As the head of one of the most famous and successful Academies in football, Nick says: “Our aim is to help instil confidence across the club’s Academy players as soon as they step through the door. These young players are looking to follow in the footsteps of regular first-teamers like Marcus Rashford, Mason Greenwood and Scott McTominay, and from experience, having confidence to be themselves is just as important as their footballing abilities within our youngest age groups.

“Our role in The Academy is not only to develop the boys as footballers, but also into well-rounded human beings who are comfortable and confident in who they are as individuals.

“We encourage all of them to showcase their own style and flair on the training pitch, which helps bring out the best of their abilities but also makes sure they enjoy the experience, too.

“I’m confident that over the coming years, we’ll continue to see exciting young players come through the Academy and into the first team.”

The partnership, which includes both the men’s and women’s teams, will see Remington and the club continue working together to deliver high-impact marketing campaigns and exceptional Remington Manchester United Collection styling products to Manchester United and Remington fans alike. The ongoing, multi-channel activation between Remington and Manchester United aims to celebrate the power of having the confidence to be yourself.

Since the launch of the partnership in 2019, Remington has created over 800 different consumer activations which have featured in over 50 different countries to a reach of over 1.1 billion Manchester United fans and followers globally. Remington’s pitch side advertising is also visible to a matchday TV audience of 3.5 billion football fans per annum.

The two global names have worked on many engaging and creative campaigns. Throughout the pandemic the Club and Remington, with the help of first team players, created useful ‘how to’ home haircut videos and fun style challenges. The latest collaboration promotes the ‘Give the Gift of Style’ a campaign featuring players Paul Pogba, David DeGea, Jadon Sancho and Edinson Cavani helping out busy fans by wrapping Remington products for well deserving recipients.

A range of Remington co-branded products are now available in over 39 markets through Remington’s outlets and globally through the online club store, with two new products added to the collection earlier this year.

Manchester United Director of Partnerships, Sean Jefferson, comments:

“As a global household name, Remington products are synonymous with style and the success of its Manchester United Collection products is testament to this. However, our partnership extends beyond the amazing product range on offer, to creating interesting and exclusive content to engage with our fans, and promoting positive messaging around finding confidence in being you.

“We are very proud to extend our relationship with Remington and look forward to continuing to build on our successful partnership.”

Tim Wright, Vice President for Appliances at Spectrum Brands Holdings comments:

“The first three years of our partnership with Manchester United have been incredibly positive and enabled us to engage with fans of the club in exciting and creative ways.

“Extending the partnership is a fantastic opportunity to continue showcasing the quality and versatility of Remington products to passionate fans of the world’s biggest and most revered sports club.”

To watch the full interview with Nick Cox, visit https://youtu.be/Q1WpfL4ElI8.

– ENDS –

Notes to Editors

For more information, please contact remington.mufc@hatchpr.co.uk. Hi-res images are available here: https://we.tl/t-PDlBjiOYOw.

About Manchester United

Manchester United plc (NYSE: MANU) is one of the most popular and successful sports teams in the world, playing one of the most popular spectator sports on earth. Through our 144-year heritage we have won 66 trophies, enabling us to develop the world’s leading sports brand and a global community of 1.1 billion followers. Our large, passionate community provides Manchester United with a worldwide platform to generate significant revenue from multiple sources, including sponsorship, merchandising, product licensing, new media and mobile, broadcasting and match day.

About Remington

As a leading and widely recognized global brand of Spectrum Brands Holdings, Remington has been helping the world get ready for more than 80 years.  Powered by decades of industry-leading innovation, Remington takes pride in being at the very cutting edge of technology. Remington works with top salon professionals from around the world to produce electrical personal care products that really work, care for you, and deliver superior results every single time. For more information about Remington, visit http://www.remingtonproducts.com/ (US) or https://eu.remington-europe.com/ (EU).

About Spectrum Brands Holdings

Spectrum Brands Holdings is a home-essentials company with a mission to make living better at home. We focus on delivering innovative products and solutions to consumers for use in and around the home through our trusted brands. We are a leading supplier of residential locksets, residential builders’ hardware, plumbing, shaving and grooming products, personal care products, small household appliances, specialty pet supplies, lawn and garden and home pest control products, and personal insect repellents. Helping to meet the needs of consumers worldwide, Spectrum Brands offers a broad portfolio of market-leading, well-known and widely trusted brands including Kwikset®, Weiser®, Baldwin®, National Hardware®, Pfister®, Remington®, George Foreman®, Russell Hobbs®, Black+Decker®, Tetra®, DreamBone®, SmartBones®, Nature’s Miracle®, 8-in-1®, FURminator®, Healthy-Hide®, Good Boy®, Meowee!® , OmegaOne®, OmegaSea®, Spectracide®, Cutter®, Repel®, Hot Shot®, Rejuvenate®, Black Flag®, and Liquid Fence®. Spectrum Brands, a member of the Russell 1000 index, generated fiscal 2020 net sales of approximately $4.0 billion. For more information visit www.spectrumbrands.com

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Image 1: Remington Extends Partnership with Manchester United

Wes Brown, Man Utd Academy graduate and Club Legend (L), chats with Nick Cox (R), Head of Academy as part of the REmington global contract extension video content

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Adagio Therapeutics Summarizes ADG20 Neutralizing Activity Against SARS-CoV-2 Variants and Outlines Initiatives to Address Omicron

Recent Publications by Several Independent Laboratories Show ADG20 Has Neutralizing Activity with Potency Comparable to Other Antibodies that Retain Activity Against Omicron

Multiple Efforts Underway to Address Omicron and Potential Future SARS-CoV-2 Variants

WALTHAM, Mass., Jan. 12, 2022 (GLOBE NEWSWIRE) — Adagio Therapeutics, Inc., (Nasdaq: ADGI), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of antibody-based solutions for infectious diseases with pandemic potential, today summarized recent findings reported in three separate publications that show ADG20, its lead monoclonal antibody (mAb), has neutralization activity against the Omicron (B.1.1.529) variant of SARS-CoV-2, and outlined initiatives to address current and future SARS-CoV-2 variants of concern. Adagio is evaluating ADG20 in its global Phase 2/3 clinical trials for both the prevention and treatment of COVID-19. Adagio is engaging with the U.S. Food and Drug Administration (FDA) regarding potential protocol updates to its global Phase 2/3 clinical trials, including an increased dose of ADG20 for the potential prevention and treatment of COVID-19 resulting from the Omicron variant.

ADG20 Neutralizing Activity Against Omicron
Recently published in vitro studies examined the neutralization potencies of large panels of mAbs against the Omicron variant in both authentic and pseudovirus assays. Findings across all three studies show that among mAbs in late-stage clinical development or with Emergency Use Authorization (EUA), ADG20 is one of only a few mAbs that demonstrated neutralizing activity against Omicron. Across two distinct authentic neutralization assays against Omicron, the data show that ADG20 had an IC50, a measurement of neutralization potency, of approximately 0.4 to 1.1 µg/mL, which is comparable with the two other active mAbs, sotrovimab and AZD7742.

“What is critical to assessing potential clinical effectiveness of SARS-CoV-2 mAbs is the neutralization potency by the mAb against a specific variant. While findings may show that ADG20 has reduced potency against Omicron when compared to its high potency against all other variants of concern, including Delta, the data support that ADG20 is among the few mAbs to demonstrate neutralizing activity against the Omicron variant and warrants its continued development,” said Laura Walker, Ph.D., chief scientific officer and co-founder of Adagio.

These data add to previously reported in vitro data from a variety of preclinical studies that showed that ADG20 retains activity against other variants of concern including Alpha, Beta, Delta and Gamma, and that ADG20 retains neutralizing activity against a diverse panel of circulating SARS-CoV-2 variants, including the Lambda, Mu and Delta plus variants.

Clinical Trial Update to Address Omicron
Adagio is continuing evaluation of ADG20 in its EVADE and STAMP clinical trials. Adagio is engaging with the FDA on dosing strategy, including an increased dose of ADG20 and other protocol updates in light of the spread of the Omicron variant. Adagio is pausing the enrollment of new patients in the 300 mg dose arm in both clinical trials as the company updates its protocols. Follow-up and monitoring of patients previously administered ADG20 are continuing per the original protocols.

Additional Efforts to Address Omicron and Future Variants
In addition to its clinical trial updates, Adagio is pursuing multiple strategies to address both Omicron and potential future variants that may emerge. Leveraging its exclusive partnership with Adimab LLC, a global leader in antibody engineering, Adagio is exploring the potential to engineer ADG20 to further improve binding to the Omicron variant to enhance its neutralization potency against Omicron while retaining its broad neutralization against other SARS-CoV-2 variants of concern. In parallel, Adagio is assessing several hundred mAbs from its proprietary library of previously isolated SARS-CoV-2 antibodies for their neutralization potency against Omicron. Such an additional neutralizing mAb could be developed as a stand-alone product or as part of a combination approach. These efforts are underway, and the company anticipates preliminary findings from its research in the first quarter of 2022.

“SARS-CoV-2 is a quickly evolving virus, and at Adagio, we are committed to adapting just as quickly. It is abundantly clear that no single product will fully address the evolving nature of the COVID-19 pandemic, and that multiple preventative and therapeutic solutions are needed. Based on both in-house data and third-party findings, we are confident that ADG20 can be an important tool in the fight against this virus,” added Tillman Gerngross, Ph.D., co-founder and chief executive officer of Adagio.

About ADG20
ADG20, an investigational monoclonal antibody targeting the spike protein of SARS-CoV-2 and related coronaviruses, is being evaluated in global clinical trials for the prevention and treatment of COVID-19, the disease caused by SARS-CoV-2. ADG20 was designed to possess high potency and broad neutralization activity against SARS-CoV-2 and additional clade 1 sarbecoviruses by targeting a highly conserved epitope in the receptor binding domain. ADG20 was further engineered to provide an extended half-life for durable protection. In vitro data from a variety of preclinical studies have shown that ADG20 retains neutralizing activity against all known SARS-CoV-2 variants of concern. In a Phase 1 trial, ADG20 was well-tolerated with no safety signals identified through a minimum of three months follow-up across all cohorts. ADG20 has not been approved for use in any country, and safety and efficacy have not yet been established.

About Adagio Therapeutics
Adagio (Nasdaq: ADGI) is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of antibody-based solutions for infectious diseases with pandemic potential, including COVID-19 and influenza. The company’s portfolio of antibodies has been optimized using Adimab’s industry-leading antibody engineering capabilities and is designed to provide patients and clinicians with the potential for a powerful combination of potency, breadth, durable protection (via half-life extension), manufacturability and affordability. Adagio’s portfolio of SARS-CoV-2 antibodies includes multiple non-competing, broadly neutralizing antibodies with distinct binding epitopes, led by ADG20. Adagio has secured manufacturing capacity for the production of ADG20 with third-party contract manufacturers to support the completion of clinical trials and initial commercial launch, ensuring the potential for broad accessibility to people around the world, if authorized or approved for use. For more information, please visit www.adagiotx.com.

Forward Looking Statements
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Contacts:
Media Contact:
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Dan@1abmedia.com

Investor Contact:
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monique@thrustsc.com

Study Nixes Mars Life in Meteorite Found in Antarctica

A 4-billion-year-old meteorite from Mars that caused a splash here on Earth decades ago contains no evidence of ancient, primitive Martian life after all, scientists reported Thursday.

In 1996, a NASA-led team announced that organic compounds in the rock appeared to have been left by living creatures. Other scientists were skeptical, and researchers chipped away at that premise over the decades, most recently by a team led by the Carnegie Institution for Science’s Andrew Steele.

Tiny samples from the meteorite show the carbon-rich compounds are actually the result of water — most likely salty, or briny, water — flowing over the rock for a prolonged period, Steele said. The findings appear in the journal Science.

During Mars’ wet and early past, at least two impacts occurred near the rock, heating the planet’s surrounding surface, before a third impact bounced it off the red planet and into space millions of years ago. The 2-kilogram (4-pound) rock was found in Antarctica in 1984.

Groundwater moving through the cracks in the rock, while it was still on Mars, formed the tiny globs of carbon that are present, according to the researchers. The same thing can happen on Earth and could help explain the presence of methane in Mars’ atmosphere, they said.

But two scientists who took part in the original study took issue with these latest findings, calling them disappointing. In a shared email, they said they stand by their 1996 observations.

“While the data presented incrementally adds to our knowledge of (the meteorite), the interpretation is hardly novel, nor is it supported by the research,” wrote Kathie Thomas-Keprta and Simon Clemett, astromaterial researchers at NASA’s Johnson Space Center in Houston.

“Unsupported speculation does nothing to resolve the conundrum surrounding the origin of organic matter” in the meteorite, they added.

According to Steele, advances in technology made his team’s new findings possible.

He commended the measurements by the original researchers and noted that their life-claiming hypothesis “was a reasonable interpretation” at the time. He said he and his team, which includes NASA, German and British scientists, took care to present their results “for what they are, which is a very exciting discovery about Mars and not a study to disprove” the original premise.

This finding “is huge for our understanding of how life started on this planet and helps refine the techniques we need to find life elsewhere on Mars, or Enceladus and Europa,” Steele said in an email, referring to Saturn and Jupiter’s moons with subsurface oceans.

The only way to prove whether Mars ever had or still has microbial life, according to Steele, is to bring samples to Earth for analysis. NASA’s Perseverance Mars rover has collected six samples for return to Earth in a decade or so; three dozen samples are desired.

Millions of years after drifting through space, the meteorite landed on an icefield in Antarctica thousands of years ago. The small gray-green fragment got its name — Allan Hills 84001 — from the hills where it was found.

Source: Voice of America