Constellation Brands Reports Second Quarter Fiscal 2022 Results

VICTOR, N.Y., Oct. 06, 2021 (GLOBE NEWSWIRE) — Constellation Brands, Inc. (NYSE: STZ and STZ.B), a leading beverage alcohol company, reported today its second quarter fiscal 2022 results. A conference call to discuss the financial results and outlook will be hosted by President and Chief Executive Officer Bill Newlands and Chief Financial Officer Garth Hankinson on Wednesday, October 6, 2021, at 10:30 a.m. (EDT).

Visit cbrands.com/investors/events to locate information for joining the conference call, or a live, listen-only webcast of the conference call.

ABOUT CONSTELLATION BRANDS
At Constellation Brands (NYSE: STZ and STZ.B), our mission is to build brands that people love because we believe sharing a toast, unwinding after a day, celebrating milestones, and helping people connect, are Worth Reaching For. It’s worth our dedication, hard work, and the bold calculated risks we take to deliver more for our consumers, trade partners, shareholders, and communities in which we live and work. It’s what has made us one of the fastest-growing large CPG companies in the U.S. at retail, and it drives our pursuit to deliver what’s next.

Today, we are a leading international producer and marketer of beer, wine, and spirits with operations in the U.S., Mexico, New Zealand, and Italy. Every day, people reach for our high-end, iconic imported beer brands such as Corona Extra, Corona Light, Corona Premier, Modelo Especial, Modelo Negra, and Pacifico, and our high-quality premium wine and spirits brands, including the Robert Mondavi Brand Family, Kim Crawford, Meiomi, The Prisoner Brand Family, SVEDKA Vodka, Casa Noble Tequila, and High West Whiskey.

But we won’t stop here. Our visionary leadership team and passionate employees from barrel room to boardroom are reaching for the next level, to explore the boundaries of the beverage alcohol industry and beyond. Join us in discovering what’s Worth Reaching For.

To learn more, follow us on Twitter @cbrands and visit www.cbrands.com.

MEDIA CONTACTS INVESTOR RELATIONS CONTACTS
Mike McGrew 773-251-4934 / michael.mcgrew@cbrands.com Patty Yahn-Urlaub 585-678-7483 / patty.yahn-urlaub@cbrands.com
Amy Martin 585-678-7141 / amy.martin@cbrands.com Marisa Pepelea 312-741-2316 / marisa.pepelea@cbrands.com

A PDF containing our Second Quarter Fiscal Year 2022 Results and full financial tables is available at: http://ml.globenewswire.com/Resource/Download/a982ffc1-cab3-498d-8e88-75975ba83f4b

Plug Power and South Korea’s SK E&S Form Joint Venture to Accelerate Expansion of Hydrogen Economy in Asian Markets

Joint Venture Enters the Asian Market by Building Gigafactory, a Base for Mass Producing Electrolyzers, Green Hydrogen and Fuel Cells

LATHAM, N.Y., Oct. 06, 2021 (GLOBE NEWSWIRE) — Plug Power Inc. (NASDAQ: PLUG), a leading provider of turnkey hydrogen solutions for the global green hydrogen economy, and SK E&S, part of South Korea’s SK Group, announced today that the companies have formed a joint venture designed to accelerate the use of hydrogen as an alternative energy source in Asian markets. Through this initiative, the two companies will collaborate to provide hydrogen fuel cell systems, hydrogen fueling stations, electrolyzers and green hydrogen to the Korean and other Asian markets.

The two companies began working together in early 2021, when SK Group made a $1.6 billion capital investment in Plug Power and announced a strategic partnership to accelerate the expansion of the hydrogen economy throughout Asia. On October 6th, executives from Plug Power and SK E&S gathered at the SK Seorin Building for a signing ceremony.

Choo Hyeongwook, the President and Chief Executive Officer of SK E&S, said: “The establishment of the joint venture is meaningful as it secures the basis to enter the Asian market based on hydrogen related core technologies owned by Plug Power. It will provide SK E&S with a unique opportunity to build a powerful hydrogen ecosystem with Plug Power, including green hydrogen production using electrolyzer technology.”

In response, Plug Power’s Chief Executive Officer Andy Marsh, who also attended the signing, said: “With SK E&S by our side, we’re incredibly proud to bring the green hydrogen revolution to South Korea and other Asian markets. Plug Power has proven its ability to scale hydrogen infrastructure quickly, expertise which aligns perfectly with SK’s exceptional local knowledge, capabilities, and vision for a green future. Here in South Korea, we’re thrilled to be working alongside SK to create a vast tapestry of hydrogen refueling stations and key hydrogen infrastructure, which will power industries throughout South Korea and beyond, while helping governments and municipalities reach sustainability goals.”

In January 2019, the South Korea government announced the Hydrogen Economy Roadmap through 2040, with ambitious goals, including: over 5 million tons of hydrogen per year, over 6 million fuel cell EVs, 1,200 refilling stations and 15 GW of fuel cell power generation, and outlined its expectation that the cumulative economic value of its hydrogen economy will reach approximately $40 billion by 2040. Plug Power has proven its ability to scale hydrogen infrastructure quickly. In North America, the company has built a robust network of over 150 hydrogen refueling stations, which are already powering hydrogen powered fleets in numerous industries, while the company’s on-site hydrogen fuel cell technology provides resilient, reliable backup power for businesses and institutions. For Plug Power, the joint venture with SK provides a unique opportunity to establish a foothold in the Asian market with one of South Korea’s leading industrial conglomerates.

The joint venture plans to build a gigafactory in a key metropolitan area in South Korea by 2024, with mass capacity for hydrogen fuel cells and electrolyzer systems and plans to supply domestic and certain overseas markets in Asia. Over time, the joint venture also plans to assume the role of distributing liquefied hydrogen produced by SK E&S to around 100 charging stations nationwide.

SK E&S and Plug Power will own 51% and 49%, respectively, of the joint venture. Plug Power and SK will hold an equal number of board seats, and any material decisions must be made unanimously.

To learn more about the potential for green hydrogen in Asia, tune into the Plug Symposium on October 14, 2021. Register today at https://cvent.me/lz49q2.

About Plug Power
Plug Power is building the hydrogen economy as the leading provider of comprehensive hydrogen fuel cell turnkey solutions. The Company’s innovative technology powers electric motors with hydrogen fuel cells amid an ongoing paradigm shift in the power, energy, and transportation industries to address climate change and energy security, while meeting sustainability goals. Plug Power created the first commercially viable market for hydrogen fuel cell technology. As a result, the Company has deployed over 40,000 fuel cell systems for e-mobility, more than anyone else in the world, and has become the largest buyer of liquid hydrogen, having built and operated a hydrogen highway across North America. Plug Power delivers a significant value proposition to end-customers, including meaningful environmental benefits, efficiency gains, fast fueling, and lower operational costs. Plug Power’s vertically-integrated GenKey solution ties together all critical elements to power, fuel, and provide service to customers such as Amazon, BMW, The Southern Company, Carrefour, and Walmart. The Company is now leveraging its know-how, modular product architecture and foundational customers to rapidly expand into other key markets including zero-emission on-road vehicles, robotics, and data centers. Learn more at www.plugpower.com.

Safe Harbor Statement
This communication contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 that involve significant risks and uncertainties about Plug Power Inc.(“PLUG”), including but not limited to statements about PLUG’s expectations regarding the timing and scope of, and plans for, the announced joint venture with SK E&S, including the building and operation of a gigafactory, the production of green hydrogen, fuel cell systems, hydrogen fueling stations and electrolyzers and the expected pricing of same, and the distribution of liquefied hydrogen, and the expectations regarding PLUG’s opportunity to establish a foothold in the hydrogen economy and the growth and expansion of the hydrogen economy in Asian markets, . You are cautioned that such statements should not be read as a guarantee of future performance or results, and will not necessarily be accurate indications of the times that, or by which, such performance or results will have been achieved. Such statements are subject to risks and uncertainties that could cause actual performance or results to differ materially from those expressed in these statements. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of PLUG in general, see PLUG’s public filings with the Securities and Exchange Commission, including the “Risk Factors” section of PLUG’s Annual Report on Form 10-K for the year ended December 31, 2020 and Quarterly Reports on Form 10-Q for the quarters ended March 31, 2021 and June 30, 2021. Readers are cautioned not to place undue reliance on these forward-looking statements. The forward-looking statements are made as of the date hereof, and PLUG undertakes no obligation to update such statements as a result of new information.

SOURCE: PLUG POWER

Plug Power Media Contact
Caitlin Coffee
Allison + Partners
plugPR@allisonpr.com

AELF FlightService Adds Fourth A330 to Fleet, Delivers COVID-19 Supplies in First Flight

AELF FlightService adds a fourth A330-200 to its fleet

AELF FlightService adds a fourth A330-200 to its fleet

CHICAGO, Oct. 06, 2021 (GLOBE NEWSWIRE) — AELF FlightService announced today that its fourth Airbus 330-200 (registered as 9H-JFS) is officially on the Maleth Aero certificate. In partnership with air charter specialist 26AVIATION, the aircraft commenced its first operational flight in auxiliary cargo configuration on Friday, Oct. 1, flying from Europe to Asia to deliver critical supplies to curb the global COVID-19 pandemic.

“With the rapid growth of e-commerce and constant need for transport of pandemic supplies, there is more than ever a need for innovative cargo solutions in the market,” said Joe Cirillo, Chief Operating Officer at AELF FlightService. “This additional aircraft allows us to expand our fleet to further meet that need.”

In 2020, together with European partners, AELF FlightService led the acquisition of the controlling interest in Malta-based airline Maleth Aero which has since added four A330s to its certificate, including this aircraft. With a total of eight widebody aircraft in full-time auxiliary cargo configuration, the airline has quickly become a leader in the fast-growing passenger to freighter (P2F) market.

“We are thrilled to add another widebody aircraft to our operation that will increase capacity and allow us to continue providing reliable, seamless and on-time service to our customers,” said Lee Jones, President of Maleth Aero.

AELF FlightService offers a full spectrum of services including single charter flights and mid-term ACMI/wet and damp leases, as well as more traditional liquidity solutions such as long-term operating leases, sale and leasebacks, sale and wet leasebacks, among other services.

For more information, visit AELF-FlightService.com.

Contact:
Natalie Matthews
nmatthews@aelf-flightservice.com
+1 312-319-4468

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Image 1: AELF FlightService adds a fourth A330-200 to its fleet

This content was issued through the press release distribution service at Newswire.com.

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VistaJet Hosts ‘The Surprise Reunion’

The Surprise Reunione

Touchdown on a VistaJet Global 7500

ASTONISHING JOURNEYS TO CELEBRATE TIME WITH FRIENDS AND FAMILY

Fully bespoke multi-generational adventures to reunite loved ones

London, October 6, 2021: Reunion noun. /ˌriːˈjuːniən/ — The act of people coming together after they have been apart for some time.

VistaJet, the first and only global business aviation company, today announced the launch of The Surprise Reunion, its latest creation in the Adventures in the Sky program for families. Designed in collaboration with world-renowned event planners Sharky & George, the thrilling adventures bring friends and families together from every corner of the globe. Whether on a little known sandy island in the Pacific Ocean or a stunning mountain with untouched snow as far as the eye can see, gatherings will be completely unique and original.

Prior to each journey, exciting and mysterious packages, including trip itineraries and challenge instructions, are delivered at each guest’s door. Perhaps an ancient map parchment, a set of engraved coins, or a cryptic message, each will be different from the next — and in some cases, delivered by unexpected characters. From there, VistaJet will ensure seamless travel by private jet from anywhere in the world, to the final destination.

With unparalleled experience flying into and out of the hardest to reach destinations and onboard service unlike any other, The Surprise Reunion flights are remarkable. As friends and family may be flying simultaneously on separate VistaJet aircraft, all in-flight activities and challenges will share a common theme to create an atmosphere of togetherness leading up to the reunion.

Matteo Atti, EVP of Marketing and Innovation at VistaJet said: “This past year has shown us that spending time with family and friends is what really matters. We assessed how to better serve our Members and imagined a reunion with loved ones of all ages, commencing at 45,000ft in the sky. In collaboration with our longstanding partner Sharky & George, we did just that by creating The Surprise Reunion.

Onboard fun

En route to reunite with family and friends

After more than a year of missed milestones and holiday gatherings, our hope is that this will give families and friends something exciting to look forward to, encouraging them to spend time together, exploring new places, creating new traditions, and celebrating every moment big and small.”

VistaJet’s Surprise Reunion can be completely tailored to meet passenger preferences and create the most imaginative experience. Inspiration itineraries include:

  • The Ultimate Quest: Imagine the world’s most elaborate treasure hunt that starts at home and culminates in all the family’s favorite people congregating on a private island surrounded by turquoise sea. Hidden maps and cryptic clues will be found along the way, interacting with characters who are not what they initially seem. Expect boat chases, drone delivery of intel, femmes fatales, buried chests, high-tech spy equipment, and a nail-biting narrative to inspire and excite all ages.
  • Adventure Race Across the Globe: Perfect for family and friends with a competitive streak. Teams are allocated one month before the VistaJet flights and are evenly split between ages, ability and geography. As soon as race packs are delivered, players will have time to collaborate on tactics and game plans. Upon arrival at the top of a mountain, in a beautiful chalet surrounded by pristine powder, the group receives a set of photos, video and physical challenges to kick off a week-long adventure, paramotoring over the peaks, tracking chamois, marmot or elk with a local biologist, and dog sledding to dinner.
  • Immersive Historical Experience: Travel back in time to Ancient Greece, where everyone will convene aboard a spectacular superyacht for two weeks in the Peloponnese to embark on a modern take on the 12 Labors of Hercules. Clues and challenges will be woven into the most unusual activities imaginable, from cave diving to capture Hydra from the bed of the sea, to recovering Golden Apples from the top of Mount Olympus in a climb to Greece’s highest peak.

For more information on VistaJet and its Adventures in the Sky offerings, please visit vistajet.com/children

– Ends –

Information
VistaJet | press@vistajet.com

About VistaJet 
VistaJet is the first and only global business aviation company. On its fleet of over 70 silver and red business jets, VistaJet has flown corporations, governments and private clients to 187 countries, covering 96% of the world. Founded in 2004, the company pioneered an innovative business model where customers have access to an entire fleet whilst paying only for the hours they fly, free of the responsibilities and asset risks linked to aircraft ownership. VistaJet’s signature Program membership offers customers a bespoke subscription of flight hours on its fleet of mid and long-range jets, to fly them anytime, anywhere.
VistaJet is part of Vista Global Holding — the world’s first private aviation ecosystem, integrating a unique portfolio of companies offering asset-light solutions to cover all key aspects of business aviation.
More VistaJet information and news at vistajet.com

VistaJet Limited is a European air carrier that operates 9H registered aircraft under its Maltese Air Operator Certificate No. MT-17 and is incorporated in Malta under Company Number C 55231. VistaJet US Inc. is an Air Charter Broker that does not operate aircraft. VistaJet and its subsidiaries are not U.S. direct carriers. VistaJet-owned and U.S. registered aircraft are operated by properly licensed U.S. air carriers, including XOJET Aviation LLC.

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Covicept Therapeutics initiates a Phase 2 clinical study with PJS-539, an oral small molecule for the treatment of patients with COVID-19 (SARS-CoV-2)

Covicept Therapeutics initiates a Phase 2 clinical study with PJS-539, an oral small molecule for the treatment of patients with COVID-19 (SARS-CoV-2)

  • Covicept has initiated a Phase 2 multi-center, randomized, double-blind, placebo-controlled 150 patient clinical trial in Brazil
  • The study will evaluate safety and efficacy of PJS-539 in reducing viral load in patients with COVID-19
  • PJS-539 is a potent, once daily, oral pill that inhibits attachment, infection and replication of SARS-CoV-2 and other RNA viruses
  • Covicept is a California-based biotech company funded and operationally supported by Forbion, a leading European life sciences venture capital firm

San Diego, USA, October 6th, 2021 – Covicept Therapeutics, an antiviral drug development company, announced today that a double-blind, placebo-controlled Phase 2 trial of PSJ-539 has been initiated and has begun enrolling patients with mild-to-moderate COVID-19. PSJ-539 has the potential to become a best-in-class small molecule for the treatment of COVID-19 patients and also has potential as a broad-spectrum antiviral drug targeting RNA viruses.

This multi-center, randomized, double-blind, placebo-controlled Phase 2 clinical trial is designed to evaluate safety and efficacy of PJS-539 in patients recently diagnosed with COVID-19. The trial in up to 150 patients is being conducted in Brazil, led by Bruno M Tomazini, MD of the Hospital do Coração São Paulo. PSJ-539 is administered once a day over ten days and the primary endpoint of the study will be the effect of two different doses of PSJ-539 on viral load compared to placebo. Secondary endpoints include the frequency of hospitalization and need for mechanical ventilation. Results are anticipated by the end of the year (1). The unique mechanism of action of PSJ-539 may prevent or minimize the development of resistance to vaccines and anti-viral medications.

Covicept has discovered several new host-dependent mechanisms by which PSJ-539 inhibits viral infections underscoring its potential as a broad-spectrum antiviral drug targeting RNA viruses (2). In addition, PSJ-539 has strong anti-inflammatory and anti-fibrotic effects in preclinical models of SARS-CoV-2-induced pneumonia. PSJ-539 has previously been tested in human clinical trials, however its anti-viral potential is novel and Covicept holds an exclusive world-wide license to the new patents.

Large scale GMP manufacturing of PSJ-539 has been established.

Professor Tsimikas, Co-Founder, Chairman and Chief Executive Officer of Covicept, commented: “It is a significant milestone for this program to move into clinical development in less than a year since Covicept was founded. Our team, together with Forbion’s operational and financial support, provides the necessary synergy to bring this medicine to patients infected with SARS-CoV-2 as quickly as possible.”

Sander van Deventer, Covicept Board member and Operating Partner at Forbion, added: “Covicept is a great example of how academic researchers, entrepreneurs, and investors can join forces and in a very agile way bring new therapeutic options to patients. PSJ-539 has potential as a prophylactic and to treat early, moderate and severe disease to reduce viral load, to minimize transmission and infection, as well as to reduce the long-term effects. We are very excited by the progress the team has made in the past nine months and continue to support the company on its way to develop potential blockbuster anti-viral drugs.”

RNA viruses such as SARS-CoV-1 (“COVID”), SARS-CoV-2 (“SARS”), MERS-CoV (“MERS”), Dengue, Chikungunya, Zika and Ebola, are considered to be the most likely causes of devastating global pandemics. Vaccination strategies can prevent the spread of these viruses and protect individuals, but they require a significant lead time before implementation and demonstration of efficacy. Hence, a small molecule that can be stockpiled and used to inhibit viral replication would be an integral component of the response to pandemics caused by RNA viruses.

Details of the Covicept PSJ-539 program and results to date will be presented later today by Dr van Deventer at the Sachs 8th Annual Healthtech Investment Forum in Basel, Switzerland in the Spotlight Showcase at 12.20pm local time.

References

  1. Clinicaltrials.gov: https://www.clinicaltrials.gov/ct2/show/NCT05008393?term=covicept&draw=2&rank=1
  2. Cell paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489987/

About Covicept Therapeutics, Inc.

Covicept Therapeutics, Inc. was founded in 2020 in San Diego, California USA, based on discoveries by Professor Sam Tsimikas, Professor Philip Gordts and Professor Jeffrey Eskowith. It is focused on the development of drugs to treat diseases caused by a variety of RNA viruses, including SARS-CoV-2. It is backed by $2.3 million in seed funding and operational support from leading European VC firm Forbion.

Covicept is developing PSJ-539, a small molecule that inhibits attachment, infection and replication of SARS-CoV-2 and other RNA viruses. PSJ-539 has shown good tolerability and high potency with excellent and high biodistribution to tissues, including the lungs, in humans allowing for relatively low daily doses. PSJ-539 also inhibits fibrosis, a property that may be valuable for patients infected with SARS-CoV-2, both short term and long-term. The unique mechanism of action of PSJ-539 may prevent or minimize the development of resistance to vaccines and anti-viral medications.

About Forbion

Forbion is a dedicated life sciences venture capital firm with offices in The Netherlands, Germany and Singapore. Forbion invests in life sciences companies that are active in the
(bio-) pharmaceutical space. Forbion manages well over EUR 1.7 billion across multiple fund strategies that cover all stages of (bio-) pharmaceutical drug development. Forbion’s current team consists of 20 life sciences investment professionals that have built an impressive performance track record since the late nineties with successful investments in over 70 companies. The firm is a signatory to the United Nations Principles for Responsible Investment. Besides financial objectives, Forbion selects investments that will positively affect the health and well-being of patients. Its investors include the EIF, through its European Recovery Programme (ERP), LfA, Dutch Venture Initiative (DVI), AMUF and EFSI facilities and KfW Capital through the Programme, “ERP – Venture Capital Fonds investments”. Forbion operates a joint venture with BGV, the manager of seed and early-stage funds, especially focused on Benelux and Germany. For more information, please visit: www.forbion.com

Contacts

Covicept Therapeutics, Inc.
Professor Tsimikas, Co-Founder, Chairman and Chief Executive Officer
Tel: +1 (0) 858 699 3528
Sander van Deventer, Covicept Board director and Forbion Operating Partner
Tel: +31 (0) 6 5498 2592

Forbion
Laura Asbjornsen, Head of Communications
Email: laura.asbjornsen@forbion.com
Tel: +31 (0) 35 699 30 00

Consilium Strategic Communications
Ashley Tapp, Sue Charles, Kris Lam
Email: Covicept@consilium-comms.com
Tel: +44 (0)20 3709 5700

Ceridian to Deliver Dayforce Payroll Across Nine New Markets

TORONTO and MINNEAPOLIS, Oct. 05, 2021 (GLOBE NEWSWIRE) — Ceridian (NYSE: CDAY; TSX: CDAY), a global leader in human capital management (HCM) technology, today announced plans to deliver Dayforce Payroll across nine new markets, including Germany, Hong Kong, Indonesia, Malaysia, Philippines, Singapore, South Korea, Taiwan, and Thailand.

Today, organizations around the world use Dayforce Payroll to reduce global compliance complexities and enable real-time auditing of payroll data to pay their people accurately and on time. Dayforce Payroll bridges the gap between pay and time, removing the pressure and burden of the traditional payroll process.

“The Dayforce platform’s continuous calculation of pay and time within a single solution has redefined how global enterprises experience payroll,” said Joe Korngiebel, Chief Product and Technology Officer, Ceridian. “We’re excited to bring Dayforce Payroll to nine new markets to drive increased business value for our customers, while delivering superior user experiences for their people.”

With ever-changing compliance and regulatory requirements, multinational organizations can achieve a competitive advantage by adopting a modern payroll solution that helps minimize risk and protect the bottom line. Ceridian seamlessly facilitates global pay in over 160 countries allowing employers to navigate their international workforces through one consolidated system, including country-specific details down to the employee level.

“We look forward to helping our customers with operations in APJ and EMEA to better navigate the complexities of today’s business world by providing accurate, compliant, and always-on payroll solutions as part of our global HCM leadership,” concluded Korngiebel.

We anticipate that Dayforce Payroll will be available in these new markets beginning in 2022. To learn more about Dayforce Payroll, visit: Ceridian.com/Payroll

About Ceridian
Ceridian. Makes Work Life Better™.
Ceridian is a global human capital management software company. Dayforce, our flagship cloud HCM platform, provides human resources, payroll, benefits, workforce management, and talent management functionality. Our platform is used to optimize management of the entire employee lifecycle, including attracting, engaging, paying, deploying, and developing people. Ceridian has solutions for organizations of all sizes. Visit Ceridian.com or follow us @Ceridian.

Forward-Looking Statement

This press release contains forward-looking statements that involve a number of risks and uncertainties. Statements that are not historical facts, and our expectations, hopes, intentions or strategies regarding the future are forward-looking statements. Forward-looking statements are based on management’s beliefs, as well as assumptions made by, and information currently available to, management. Because such statements are based on expectations as to the future and are not statements of fact, actual results may differ materially from those projected. We undertake no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.

This press release should be read in conjunction with the risks detailed in the “Cautionary Note Regarding Forward-Looking Information,” “Forward-Looking Statement”, “Risk Factors” and other sections of Ceridian’s Quarterly Reports on Form 10-Q, Annual Reports on Form 10-K and other filings with the Securities and Exchange Commission.

Media Contact:

Fahd Pasha
647.417.2136
Fahd.Pasha@Ceridian.com

WHO Backs Malaria Vaccinations for African Children

The World Health Organization recommended Wednesday that children in sub-Saharan Africa and other regions on the continent with moderate-to-high malaria transmission receive a malaria vaccine.

The vaccine, known as Mosquirix, proved effective in a pilot program in Ghana, Kenya and Malawi that has reached more than 800,000 children since 2019.

The WHO said malaria is a top killer of children in sub-Saharan Africa, causing the deaths of more than 260,000 children under age 5 every year.

The vaccine, which requires four doses, counters P. falciparum, “the most deadly malaria parasite globally, and the most prevalent in Africa,” WHO said in a press release.

“For centuries, malaria has stalked sub-Saharan Africa, causing immense personal suffering,” Dr. Matshidiso Moeti, WHO regional director for Africa, said in a statement. “We have long hoped for an effective malaria vaccine and now for the first time ever, we have such a vaccine recommended for widespread use. Today’s recommendation offers a glimmer of hope for the continent which shoulders the heaviest burden of the disease and we expect many more African children to be protected from malaria and grow into healthy adults.”

Substantial benefit

According to WHO, pilot program data showed that more than two-thirds of children who were not sleeping under bed nets were benefiting from the vaccine, and that there was a 30% reduction in “deadly severe malaria, even when introduced in areas where insecticide-treated nets are widely used and there is good access to diagnosis and treatment.”

The pilot program also found that the vaccine had a “favorable safety profile” and was “cost effective.”

According to The Wall Street Journal, it could still be years until the vaccine is widely available.

The vaccine has been under development for 30 years by GlaxoSmithKline, a global pharmaceutical company; PATH, a global nonprofit focused on health issues; and some African research organizations, WHO said.

The Bill & Melinda Gates foundation provided late-stage development funding for the vaccine, WHO said.

Source: Voice of America

Americans Being Warned of Deadly Fake Medication

Americans are being warned to beware of potentially deadly fake prescription pills that are laced with the powerful opioid fentanyl and the highly addictive stimulant methamphetamine. The counterfeit tablets are linked to a wave of drug overdoses killing unsuspecting users.

In its first warning in six years, the Drug Enforcement Administration (DEA) said international and domestic criminal networks were mass-producing fake pills and falsely marketing them as legitimate prescription medication.

“Counterfeit pills that contain these dangerous and extremely addictive drugs are more lethal and more accessible than ever before,” said DEA Administrator Anne Milgram at a news conference in Washington.

The notification was issued last week after the DEA announced it had seized more than 1.8 million fake pills during a two-month undercover operation and had arrested more than 810 people. In a statement, the agency said it had confiscated more than 9.5 million potentially lethal pills in the last year.

“Illicit fentanyl was responsible for nearly three-quarters of the more than 93,000 fatal drug overdoses in the United States in 2020,” said Deputy Attorney General Lisa Monaco. Health officials report fentanyl was responsible for nearly 70,000 of the overdose deaths.

Powerful pills

U.S. law enforcement investigators say the majority of counterfeit medication found in America is being made in labs in Mexico using chemicals imported from China. The DEA believes Chinese traffickers have switched from primarily manufacturing finished fentanyl to exporting precursors of the synthetic opioid to Mexican cartels, which then manufacture illicit fentanyl. U.S. officials are now seeking greater cooperation from Mexican law enforcement agencies to disrupt trafficking in the country.

DEA laboratory testing revealed that two out of five fentanyl-laced fake pills seized contained a potentially deadly dose of just 2 milligrams. Fentanyl can be 100 times more powerful than morphine. Drug researchers say a deadly dose of fentanyl is small enough to fit on the tip of a pencil.

“The fake pills seized were capable of killing more than 700,000 people,” Milgram noted, adding that law enforcement agencies have sought to shut down criminal distribution networks selling tablets that look exactly like name-brand prescription medications. “We are alerting the public to this danger so that people have the information they need to protect themselves and their children.”

The DEA alert said medications prescribed by doctors and dispensed by licensed pharmacists were safe, but pills acquired by other avenues were potentially deadly.

Decades of death

Since 1999, more than 500,000 Americans have died of opioid overdoses, both prescription and nonprescription. Deaths rose in nearly all states, with the highest increases in California, Kentucky, Vermont, South Carolina and West Virginia, according to the Centers for Disease Control and Prevention.

The more than 9.5 million fake tablets seized this year represented 430% more than the number seized in 2019. The DEA also confiscated ingredients used to make tens of millions of pills, including more than 4,000 kilograms of methamphetamine.

“The pervasiveness of these illicit drugs, and the fatal overdoses that too often result, is a problem that cuts across America from small towns to big cities and everything in between,” said Monaco.

The most common counterfeit pills are being made to look identical to prescription medications such as Oxycontin, Xanax, Vicodin or stimulants like amphetamines. Investigators say the fake medications are widely available and sold on social media platforms as well as on the streets.

“The illicit drug supply introduces even greater uncertainty about what people are taking, and that contributes to overdoses.” Dr. Caleb Alexander, a professor of epidemiology and medicine at the Johns Hopkins Bloomberg School of Public Health in Baltimore, Maryland, told VOA. “If someone combines fentanyl with heroin or methamphetamine or another illicit product, it can be deadly.”

Source: Voice of America